Reversibility of phosphorylase kinase reaction.
نویسندگان
چکیده
منابع مشابه
The muscle phosphorylase b kinase reaction.
The conversion of skeletal muscle phosphorylase b to phosphorylase a is catalyzed by an enzyme requiring ATP’ and a divalent metal (1). In this reaction phosphate is transferred from the nucleotide to phosphorylase, and a dimerization of the enzyme occurs (2). The dimer-monomer relationship existing between phosphorylases a and b was noted originally by Keller and Cori in their work on the phos...
متن کاملReversibility of a phosphoroclastic reaction.
Reaction 1 occurring with reaction 2 involves carbon dioxide fixation. Koepsell & Johnson (1942) obtained a cell-free extract from Clo8tridium butylicum which converts pyruvic acid into acetic acid, carbon dioxide and hydrogen, and requires phosphate for the reaction. Later Koepsell, Johnson & Meek (1944) found that inorganic phosphate is taken up and labile phosphate appears. The overall react...
متن کاملLiver Phosphorylase Kinase
a deficiency of liver phosphorylase kinase, causing a lack of active glycogen phosphorylase, although total phosphorylase is normal. The intravenous injection of glucagon caused a rapid activation of cyclic AMP-dependent protein kinase in the liver, but no increase in either phosphorylase kinase or phosphorylase a activity. Although total glycogen synthase activity in the livers of affected rat...
متن کاملLiver Glycogen Phosphorylase Kinase
Liver glycogen phosphorylase kinase was assayed by measuring the radioactivity of [y-32P]ATP incorporated into rabbit skeletal muscle phosphorylase b. Using this assay two forms of phosphorylase kinase, Kinase I and Kinase II, were pirified about 70and 130-fold, respectively, from rabbit liver cytosol by DEAE-Sephadex A50 column chromatography, ammonium sulfate fractionation, gel filtration on ...
متن کاملCardiac Phosphorylase Kinase
We have documented previously that although the phosphorylation of the p subunit of cardiac phosphorylase kinase plays a major role in activation of the enzyme, enzyme activity is also modulated by either CAMP-dependent or CAMP-independent phosphorylation of the a’ subunit (Sul, H. S., Cooper R. H., Whitehouse s., and Walsh D. A. (1982) J. Biol. Chem. 257, 3484-3490). This paper reports that de...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1977
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)40406-6